Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.

BMC genomics - 7 Oct 2008

van Boxtel Ruben, Toonen Pim W, Verheul Mark, van Roekel Henk S, Nijman Isaac J, Guryev Victor, Cuppen Edwin

Abstract excerpt

BACKGROUND: The laboratory rat (Rattus norvegicus) is one of the preferred model organisms in physiological and pharmacological research, although the availability of specific genetic models, especially gene knockouts, is limited. N-ethyl-N-nitrosourea (ENU)-driven target-selected mutagenesis is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkylating Agents
Share to Animals, Genetically Modified
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylnitrosourea

Share to Fertility

Share to Mutagenesis

Share to Mutagenesis, Site-Directed

Share to Rats, Wistar

Source

Open in PubMed Open full text

Identifiers

PMID: 18840264
DOI: 10.1186/1471-2164-9-460
PMCID: PMC2567347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18840264-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.PMID 18840264Read ↗

ENU mutagenesis to generate genetically modified rat models.Semantic proximity Read ↗

Systematic generation of in vivo G protein-coupled receptor mutants in the rat.Semantic proximity Read ↗

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.Semantic proximity Read ↗

ENU mutagenesis, a way forward to understand gene function.Semantic proximity Read ↗

ENU-induced phenovariance in mice: inferences from 587 mutations.Semantic proximity Read ↗

Adopting Duplex Sequencing™ Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed RatsSemantic proximity Read ↗

Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.Semantic proximity Read ↗

Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics.Semantic proximity Read ↗

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.Semantic proximity Read ↗

ENU-induced mutant mice for a next-generation gene-targeting system.Semantic proximity Read ↗

Mouse ENU mutagenesis.Semantic proximity Read ↗

Mouse mutagenesis-systematic studies of mammalian gene function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.