Article
Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2011
Nguyen Nhung, Judd Louise M, Kalantzis Anastasia, Whittle Belinda, Giraud Andrew S, van Driel Ian R
Abstract excerpt
Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene function and discover new biological pathways. Phenotype-driven approaches have the advantage of making no assumptions about the function of genes and their products and have been successfully applied to the discovery of novel gene-phenotype relationships in many physiological systems. ENU mutagenesis of mice is...
Topics
- Animals
- Breeding
- Disease Models, Animal
- Ethylnitrosourea
- Female
- Genes
- Genome
- Genome-Wide Association Study
- Inflammatory Bowel Diseases
- Male
- Mice
- Mutagenesis
- Phenotype