Article
ENU mutagenesis, a way forward to understand gene function.
Annual review of genomics and human genetics - 1 Jan 2008
Acevedo-Arozena Abraham, Wells Sara, Potter Paul, Kelly Michelle, Cox Roger D, Brown Steve D M
Abstract excerpt
Arguably, the main challenge for contemporary genetics is to understand the function of every gene in a mammalian genome. The mouse has emerged as a model for this task because its genome can be manipulated in a number of ways to study gene function or mimic disease states. Two complementary genetic approaches can be used to generate mouse models. A reverse genetics or gene-driven approach (gene to phenotype)...
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