Article
Systematic generation of in vivo G protein-coupled receptor mutants in the rat.
The pharmacogenomics journal - 1 Oct 2011
van Boxtel R, Vroling B, Toonen P, Nijman I J, van Roekel H, Verheul M, Baakman C, Guryev V, Vriend G, Cuppen E
Abstract excerpt
G-protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors that are involved in a wide range of physiological and pathological processes, and are targets for many therapeutic interventions. However, genetic models in the rat, one of the most widely used model organisms in physiological and pharmacological research, are largely lacking. Here, we applied N-ethyl-N-nitrosourea...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.