Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.

Carcinogenesis - 1 Jun 2008

van Boxtel Ruben, Toonen Pim W, van Roekel Henk S, Verheul Mark, Smits Bart M G, Korving Jeroen, de Bruin Alain, Cuppen Edwin

Abstract excerpt

To understand genetic instability in relation to tumorigenesis, experimental animal models have proven very useful. The DNA mismatch repair (MMR) machinery safeguards genomic integrity by repairing mismatches, insertion or deletion loops and responding to genotoxic agents. Here, we describe the functional characterization of a novel rat mutant model in which the MMR gene Msh6 has been genetically inactivated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkylating Agents
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Western

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Ethylnitrosourea

Share to Microsatellite Instability

Share to Mutagenesis, Site-Directed

Share to Point Mutation

Source

Identifiers

PMID: 18417481
DOI: 10.1093/carcin/bgn094

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.PMID 18417481Read ↗

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.Semantic proximity Read ↗

Mouse models of DNA mismatch repair in cancer research.Semantic proximity Read ↗

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.Semantic proximity Read ↗

Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition.Semantic proximity Read ↗

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility.Semantic proximity Read ↗

Functional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients.Semantic proximity Read ↗

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.Semantic proximity Read ↗

Mouse models for human DNA mismatch-repair gene defects.Semantic proximity Read ↗

The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.Semantic proximity Read ↗

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.Semantic proximity Read ↗

Mismatch repair defects in human carcinogenesis.Semantic proximity Read ↗

Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.