ENU-induced mutant mice for a next-generation gene-targeting system.

doi:10.1016/S0079-6123(09)17904-9

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Article

ENU-induced mutant mice for a next-generation gene-targeting system.

Progress in brain research - 1 Jan 2009

Gondo Yoichi, Fukumura Ryutaro

Abstract excerpt

By the N-ethyl-N-nitrosourea (ENU)-based gene-driven mutagenesis, it is now possible to obtain allelic series of mutant mouse strains, each of which carries a different base substitution in any target gene. This new reverse genetic tool has become available based on the ENU mutant mouse library. The ENU mutant mouse library consists of dual archives of frozen sperm and corresponding genomic DNA derived from...

Topics

Animals
Chromosome Mapping
Ethylnitrosourea
Gene Expression Regulation
Gene Targeting
Genomic Library
Male
Mice
Mice, Mutant Strains
Mutagenesis
Mutagens
Mutation

Source

Open in PubMed

Identifiers

PMID: 20302815
DOI: 10.1016/S0079-6123(09)17904-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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