Article
Probing the relationship between alpha-helix formation and calcium affinity in troponin C: 1H NMR studies of calcium binding to synthetic and variant site III helix-loop-helix peptides.
Biochemistry - 27 Aug 1991
Shaw G S, Hodges R S, Sykes B D
Abstract excerpt
Three 34-residue peptides corresponding to the high-affinity calcium-binding site III and two variant sequences from the muscle protein troponin C (TnC) were synthesized by solid-phase techniques. The two variant 34-residue peptides had amino acid modifications at either the coordinating position...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Calcium-Binding Proteins
- Chickens
- Genetic Variation
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Peptides
- Protein Binding
- Protein Conformation
- Structure-Activity Relationship
- Troponin
- Troponin C