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Article

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.

The Journal of biological chemistry - 14 Jul 2017

Stevens Charles M, Rayani Kaveh, Singh Gurpreet, Lotfalisalmasi Bairam, Tieleman D Peter, Tibbits Glen F

Abstract excerpt

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca2+ TnC binding Ca2+ initiates a cascade of protein-protein interactions that begins with the opening of the N-terminal domain of cTnC, followed by cTnC binding the troponin I switch peptide (TnISW). We have evaluated, through isothermal titration calorimetry and molecular-dynamics simulation, the effect of...

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Identifiers

PMID: 28533433
DOI: 10.1074/jbc.M116.770776
PMCID: PMC5512083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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