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Article

Calcium affinity of regulatory sites in skeletal troponin-C is attenuated by N-cap mutations of helix C.

Archives of biochemistry and biophysics - 15 Dec 2000

Leblanc L, Bennet A, Borgford T

Abstract excerpt

Site-directed mutagenesis was used to make amino acid substitutions at position 54 of skeletal troponin C, testing a relationship between the stability of helix C and calcium ion affinity at regulatory sites in the protein. Normally, threonine at position 54 is the first helical residue, or N-cap, of the C helix; where helices C and D, and the loop between, comprise binding site II. Mutations were made in the...

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Source

Identifiers

PMID: 11368316
DOI: 10.1006/abbi.2000.2103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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