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Article

Tuning the affinity for lanthanides of calcium binding proteins.

Biochemistry - 8 Jul 2003

Bertini Ivano, Gelis Ioannis, Katsaros Nikolaos, Luchinat Claudio, Provenzani Alessandro

Abstract excerpt

The possibility of selectively substituting one or more lanthanides into the four canonical calcium binding sites of calcium-loaded vertebrate calmodulin (CaM) was investigated by monitoring changes in the (1)H-(15)N HSQC NMR spectra of the (15)N-enriched protein upon titration with Yb(3+). The affinity of lanthanides for both N-terminal sites I and II is only moderately higher than that of calcium, and...

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Identifiers

PMID: 12834353
DOI: 10.1021/bi034494z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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