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Article

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Physiological genomics - 7 Jul 2010

Palpant Nathan J, Houang Evelyne M, Delport Wayne, Hastings Kenneth E M, Onufriev Alexey V, Sham Yuk Y, Metzger Joseph M

Abstract excerpt

In cardiac muscle, the troponin (cTn) complex is a key regulator of myofilament calcium sensitivity because it serves as a molecular switch required for translating myocyte calcium fluxes into sarcomeric contraction and relaxation. Studies of several species suggest that ectotherm chordates have myofilaments with heightened calcium responsiveness. However, genetic polymorphisms in cTn that cause increased...

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Identifiers

PMID: 20423961
DOI: 10.1152/physiolgenomics.00033.2010
PMCID: PMC3032286

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Source receipt: pubmed, retrieved 7 Sept 2026.

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