Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Troponin-C mutants with increased calcium affinity.

European journal of biochemistry - 1 Apr 1993

da Silva A C, de Araujo A H, Herzberg O, Moult J, Sorenson M, Reinach F C

Abstract excerpt

Binding of two Ca2+ to the regulatory sites I and II of troponin C (TnC) induces a conformational transition believed to be responsible for the activation of muscle contraction. Based on the known crystal structure (2Ca2+ state), a model for the transition to the 4Ca2+ state has been proposed [Herzberg, O., Moult, J. & James, M. N. G. (1986) J. Biol. Chem. 261, 2638-2644]. The proposed conformational transition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Calcium
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscles

Share to Mutation

Share to Protein Conformation

Share to Rabbits

Share to Recombinant Proteins

Source

Identifiers

PMID: 8477730
DOI: 10.1111/j.1432-1033.1993.tb17799.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Troponin-C mutants with increased calcium affinity.PMID 8477730Read ↗

Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.Semantic proximity Read ↗

Mutation of the high affinity calcium binding sites in cardiac troponin C.Semantic proximity Read ↗

Calcium affinity of regulatory sites in skeletal troponin-C is attenuated by N-cap mutations of helix C.Semantic proximity Read ↗

Probing the calcium-induced conformational transition of troponin C with site-directed mutants.Semantic proximity Read ↗

Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Semantic proximity Read ↗

Intramolecular interactions in the N-domain of cardiac troponin C are important determinants of calcium sensitivity of force development.Semantic proximity Read ↗

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.Semantic proximity Read ↗

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.Semantic proximity Read ↗

Mutations in the N- and D-helices of the N-domain of troponin C affect the C-domain and regulatory function.Semantic proximity Read ↗

Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II.Semantic proximity Read ↗

Increasing mammalian cardiomyocyte contractility with residues identified in trout troponin C.Semantic proximity Read ↗

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.