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Article

Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.

The Journal of biological chemistry - 20 Aug 2004

Tikunova Svetlana B, Davis Jonathan P

Abstract excerpt

Cardiac troponin C belongs to the EF-hand superfamily of calcium-binding proteins and plays an essential role in the regulation of muscle contraction and relaxation. To follow calcium binding and exchange with the regulatory N-terminal domain (N-domain) of human cardiac troponin C, we substituted Phe at position 27 with Trp, making a fluorescent cardiac troponin C(F27W). Trp(27) accurately reported the kinetics...

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Source

Identifiers

PMID: 15205455
DOI: 10.1074/jbc.M405413200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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