Article
HIV-1 with multiple CCR5/CXCR4 chimeric receptor use is predictive of immunological failure in infected children.
PloS one - 29 Sept 2008
Cavarelli Mariangela, Karlsson Ingrid, Zanchetta Marisa, Antonsson Liselotte, Plebani Anna, Giaquinto Carlo, Fenyö Eva Maria, De Rossi Anita, Scarlatti Gabriella
Abstract excerpt
BACKGROUND: HIV-1 R5 viruses are characterized by a large phenotypic variation, that is reflected by the mode of coreceptor use. The ability of R5 HIV-1 to infect target cells expressing chimeric receptors between CCR5 and CXCR4 (R5(broad) viruses), was shown to correlate with disease stage in HIV-1 infected adults. Here, we ask the question whether phenotypic variation of R5 viruses could play a role also in...
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