Article
Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection.
Retrovirology - 16 Sept 2013
Cashin Kieran, Jakobsen Martin R, Sterjovski Jasminka, Roche Michael, Ellett Anne, Flynn Jacqueline K, Borm Katharina, Gouillou Maelenn, Churchill Melissa J, Gorry Paul R
Abstract excerpt
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is spreading rapidly and is now responsible for >50% of HIV-1 infections worldwide, and >95% of infections in southern Africa and central Asia. These regions are burdened with the overwhelming majority of HIV-1 infections, yet we know very little about the pathogenesis of C-HIV. In addition to CCR5 and CXCR4, the HIV-1 envelope...
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