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Article

Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C.

Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2011

Coetzer Mia, Nedellec Rebecca, Cilliers Tonie, Meyers Tammy, Morris Lynn, Mosier Donald E

Abstract excerpt

BACKGROUND: Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-1 infection than in subtype B for reasons that are unclear. We have examined sequential virus samples from a subtype C-infected child who had evidence of coreceptor switching. METHODS: To examine HIV-1 envelope evolution towards CXCR4 usage, env sequences were correlated with phenotypic characteristics determined by entry assays,...

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Topics

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Share to Cloning, Molecular
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to Phylogeny

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Recombination, Genetic

Source

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Identifiers

PMID: 20921899
DOI: 10.1097/QAI.0b013e3181f63906
PMCID: PMC3006070

Genes

CXCR4
CCR3
CCR8
CCR1
CCR5
CCR6
CMKLR1
CXCR6
GPR15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C.PMID 20921899Read ↗

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