Article
Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C.
Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2011
Coetzer Mia, Nedellec Rebecca, Cilliers Tonie, Meyers Tammy, Morris Lynn, Mosier Donald E
Abstract excerpt
BACKGROUND: Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-1 infection than in subtype B for reasons that are unclear. We have examined sequential virus samples from a subtype C-infected child who had evidence of coreceptor switching. METHODS: To examine HIV-1 envelope evolution towards CXCR4 usage, env sequences were correlated with phenotypic characteristics determined by entry assays,...
Topics
- Child
- Cloning, Molecular
- HIV Infections
- HIV-1
- Humans
- Molecular Sequence Data
- Phenotype
- Phylogeny
- Receptors, CCR5
- Receptors, CXCR4
- Receptors, Formyl Peptide