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Article

HIV biological variability unveiled: frequent isolations and chimeric receptors reveal unprecedented variation of coreceptor use.

AIDS (London, England) - 5 Dec 2003

Karlsson Ingrid, Antonsson Liselotte, Shi Yu, Karlsson Anders, Albert Jan, Leitner Thomas, Olde Björn, Owman Christer, Fenyö Eva Maria

Abstract excerpt

OBJECTIVE: To follow the evolution of coreceptor use in HIV-1-infected individuals with varying rates of disease progression. METHODS: The coreceptor use of 278 sequential HIV-1 isolates from 23 individuals was tested by infection of two human cell lines, U87.CD4 and GHOST(3), expressing CD4 and CCR1, CCR2b, CCR3, CCR5, CXCR4, CXCR6 or BOB. Differences in coreceptor use were further dissected by testing chimeric...

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Source

Identifiers

PMID: 14685050
DOI: 10.1097/01.aids.0000096853.36052.36

Genes

CXCR4
CCR5
CCR1
CCR3
CXCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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