Article
Phenotypic Coreceptor Tropism in Perinatally HIV-infected Youth Failing Antiretroviral Therapy.
The Pediatric infectious disease journal - 1 Jul 2016
Agwu Allison L, Yao Tzy-Jyun, Eshleman Susan H, Patel Kunjal, Huang Wei, Burchett Sandra K, Siberry George K, Van Dyke Russell B
Abstract excerpt
BACKGROUND: Perinatally HIV-infected (PHIV) children and youth are often heavily treatment-experienced, with resultant antiretroviral resistance and limited treatment options. For those with virologic failure (VF), new agents such as CCR5 (R5) antagonists may be useful; however, reports of R5 antagonist susceptibility in children have mostly relied on genotypic testing, which may not accurately reflect the...
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