Article
Flexible use of CCR5 in the absence of CXCR4 use explains the immune deficiency in HIV-1 infected children.
AIDS (London, England) - 23 Oct 2010
Cavarelli Mariangela, Karlsson Ingrid, Ripamonti Chiara, Plebani Anna, Fenyo Eva Maria, Scarlatti Gabriella
Abstract excerpt
DESIGN: CCR5-using HIV-1 (R5 viruses) are usually isolated during acute infection from both adults and children. We have recently demonstrated that R5 viruses with a flexible use of CCR5 (called R5broad) can be detected in children close to birth and are predictive of a fast immunological failure. The aim of the present work was to investigate viral phenotype variation during disease progression in HIV-1 infected...
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