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Article

Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase.

Nature structural & molecular biology - 1 Oct 2008

Nowarski Roni, Britan-Rosich Elena, Shiloach Tamar, Kotler Moshe

Abstract excerpt

Deamination of cytidine residues in single-stranded DNA (ssDNA) is an important mechanism by which apolipoprotein B mRNA-editing, catalytic polypeptide-like (APOBEC) enzymes restrict endogenous and exogenous viruses. The dynamic process underlying APOBEC-induced hypermutation is not fully understood. Here we show that enzymatically active APOBEC3G can be detected in wild-type Vif(+) HIV-1 virions, albeit at low...

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PMID: 18820687
DOI: 10.1038/nsmb.1495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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