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Article

Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.

The Journal of biological chemistry - 4 May 2012

Senavirathne Gayan, Jaszczur Malgorzata, Auerbach Paul A, Upton Thomas G, Chelico Linda, Goodman Myron F, Rueda David

Abstract excerpt

APOBEC3G (Apo3G) is a single-stranded (ss)DNA cytosine deaminase that eliminates HIV-1 infectivity by converting C → U in numerous small target motifs on the minus viral cDNA. Apo3G deaminates linear ssDNA in vitro with pronounced spatial asymmetry favoring the 3' → 5' direction. A similar polarity observed in vivo is believed responsible for initiating localized C → T mutational gradients that inactivate the...

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Identifiers

PMID: 22362763
DOI: 10.1074/jbc.M112.342790
PMCID: PMC3346118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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