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Article

RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.

PLoS pathogens - 1 Mar 2009

Huthoff Hendrik, Autore Flavia, Gallois-Montbrun Sarah, Fraternali Franca, Malim Michael H

Abstract excerpt

The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of retroviruses and transposable elements and is able to deaminate cytidines to uridines in single-stranded DNA replication intermediates. A3G contains two canonical cytidine deaminase domains (CDAs), of which only the C-terminal one is known to mediate cytidine deamination. By exploiting the crystal structure of the related tetrameric APOBEC2 (A2)...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19266078
DOI: 10.1371/journal.ppat.1000330
PMCID: PMC2646141

Genes

APOBEC2
CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.PMID 19266078Read ↗

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