Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.

Journal of molecular biology - 29 Jul 2011

Britan-Rosich Elena, Nowarski Roni, Kotler Moshe

Abstract excerpt

In the absence of human immunodeficiency virus type 1 (HIV-1) Vif protein, the host antiviral deaminase apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (A3G) restricts the production of infectious HIV-1 by deamination of dC residues in the negative single-stranded DNA produced by reverse transcription. The Vif protein averts the lethal threat of deamination by precluding the packaging of A3G...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-3G Deaminase
Share to Cell Line
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptides

Share to Protein Structure, Tertiary

Share to vif Gene Products, Human Immunodeficiency Virus

Share to Virion

Source

Open in PubMed Open full text

Identifiers

PMID: 21763507
DOI: 10.1016/j.jmb.2011.03.058
PMCID: PMC3139112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.PMID 21763507Read ↗

APOBEC3G-Mediated G-to-A Hypermutation of the HIV-1 Genome: The Missing Link in Antiviral Molecular MechanismsSemantic proximity Read ↗

Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3GSemantic proximity Read ↗

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them AllSemantic proximity Read ↗

Distinct Determinants in HIV-1 Vif and Human APOBEC3 Proteins Are Required for the Suppression of Diverse Host Anti-Viral ProteinsSemantic proximity Read ↗

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.Semantic proximity Read ↗

Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.Semantic proximity Read ↗

A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.Semantic proximity Read ↗

Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection.Semantic proximity Read ↗

Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.Semantic proximity Read ↗

Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 FamilySemantic proximity Read ↗

HIV-1 Viral Infectivity Factor (Vif) Alters Processive Single-stranded DNA Scanning of the Retroviral Restriction Factor APOBEC3G*Semantic proximity Read ↗

Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.