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Article

Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.

The Journal of biological chemistry - 31 Aug 2012

Love Robin P, Xu Huixin, Chelico Linda

Abstract excerpt

APOBEC3A belongs to a family of single-stranded DNA (ssDNA) DNA cytosine deaminases that are known for restriction of HIV through deamination-induced mutational inactivation, e.g. APOBEC3G, or initiation of somatic hypermutation and class switch recombination (activation-induced cytidine deaminase). APOBEC3A, which is localized to both the cytoplasm and nucleus, not only restricts HIV but can also initiate...

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Identifiers

PMID: 22822074
DOI: 10.1074/jbc.M112.393181
PMCID: PMC3436324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.PMID 22822074Read ↗

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APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.Semantic proximity Read ↗

Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 FamilySemantic proximity Read ↗

Antiretroviral APOBEC3 Cytidine Deaminases Alter HIV-1 Provirus Integration Site ProfilesSemantic proximity Read ↗

Deaminase Activity on Single-stranded DNA (ssDNA) Occurs in Vitro when APOBEC3G Cytidine Deaminase Forms Homotetramers and Higher-order ComplexesSemantic proximity Read ↗

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.Semantic proximity Read ↗

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structureSemantic proximity Read ↗

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