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Article

APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.

Nature structural & molecular biology - 1 May 2006

Chelico Linda, Pham Phuong, Calabrese Peter, Goodman Myron F

Abstract excerpt

Akin to a 'Trojan horse,' APOBEC3G DNA deaminase is encapsulated by the HIV virion. APOBEC3G facilitates restriction of HIV-1 infection in T cells by deaminating cytosines in nascent minus-strand complementary DNA. Here, we investigate the biochemical basis for C --> U targeting. We observe that APOBEC3G binds randomly to single-stranded DNA, then jumps and slides processively to deaminate target motifs. When...

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Identifiers

PMID: 16622407
DOI: 10.1038/nsmb1086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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