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Article

Clinical severity correlates with impaired barrier in filaggrin-related eczema.

The Journal of investigative dermatology - 1 Mar 2009

Nemoto-Hasebe Ikue, Akiyama Masashi, Nomura Toshifumi, Sandilands Aileen, McLean W H Irwin, Shimizu Hiroshi

Abstract excerpt

Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, have been shown to be a major predisposing factor for atopic dermatitis (AD; eczema). To elucidate the pathomechanisms underlying filaggrin-related AD, we investigated stratum corneum (SC) hydration and transepidermal water loss (TEWL) as parameters of barrier function in AD patients harboring FLG mutations compared...

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Source

Identifiers

PMID: 18818676
DOI: 10.1038/jid.2008.280

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical severity correlates with impaired barrier in filaggrin-related eczema.PMID 18818676Read ↗

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