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Revisiting the Roles of Filaggrin in Atopic Dermatitis

10 May 2022

Abstract excerpt

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology research community and shed new light on a skin protein that was first identified in 1981. However, although outstanding work has uncovered several key functions of filaggrin in epidermal homeostasis, a comprehensive understanding of...

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PMID: 35628125
DOI: 10.3390/ijms23105318

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