Article
Severe skin inflammation and filaggrin mutation similarly alter the skin barrier in patients with atopic dermatitis.
The British journal of dermatology - 1 Mar 2014
Mócsai G, Gáspár K, Nagy G, Irinyi B, Kapitány A, Bíró T, Gyimesi E, Tóth B, Maródi L, Szegedi A
Abstract excerpt
BACKGROUND: Filaggrin (FLG) deficiency is a well-known predisposing factor for the development of atopic dermatitis (AD). Decreased FLG expression can be the result of haploinsufficiency or severe inflammation, which can cause acquired FLG alterations. FLG mutations are related to several clinical and laboratory parameters of AD; however, some recent data seem to contradict these associations. OBJECTIVES: Our aim...
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