Article
Filaggrin-gene mutation has minimal effect on the disease severity in the lesions of atopic dermatitis.
The Journal of dermatology - 1 Nov 2021
Ota Masataka, Sasaki Takashi, Ebihara Tamotsu, Yokosawa Emiko, Murakami Yumi, Matsunaka Hiroshi, Chinuki Yuko, Amagai Masayuki, Morita Eishin
Abstract excerpt
Loss-of-function mutations of filaggrin (FLG) gene (FLG) are the strongest known genetic risk factor for atopic dermatitis (AD). It is still debatable how FLG gene mutations and the resulting abnormal amount of FLG protein contribute to skin barrier function and symptoms of AD. In this study, we examined the effects of loss-of-function mutations of FLG gene on the severity of skin lesions and skin barrier...
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