Article
Atopic eczema and the filaggrin story.
Seminars in cutaneous medicine and surgery - 1 Jun 2008
Brown Sara J, Irvine Alan D
Abstract excerpt
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema represents the single most significant breakthrough in understanding the genetic basis of this complex disorder. The association has been replicated in multiple independent studies during the past 2 years with the use of various methodologies, from populations in Europe, the United States, and Japan. Filaggrin plays a...
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