Article
Filaggrin gene defects and the risk of developing allergic disorders.
Allergology international : official journal of the Japanese Society of Allergology - 1 Mar 2011
Osawa Rinko, Akiyama Masashi, Shimizu Hiroshi
Abstract excerpt
Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and formation of the skin barrier. Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris (IV) and have been shown to be major predisposing factors for atopic dermatitis (AD). Approximately 40 loss-of-function FLG mutations have been identified in patients with ichthyosis vulgaris...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.