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Article

Filaggrin gene defects and the risk of developing allergic disorders.

Allergology international : official journal of the Japanese Society of Allergology - 1 Mar 2011

Osawa Rinko, Akiyama Masashi, Shimizu Hiroshi

Abstract excerpt

Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and formation of the skin barrier. Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris (IV) and have been shown to be major predisposing factors for atopic der...

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Identifiers

PMID: 21173567
DOI: 10.2332/allergolint.10-RAI-0270

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21173567-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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