Filaggrin‐2 barrier protein inversely varies with skin inflammation

Abstract excerpt

Atopic dermatitis (AD) is a common chronic, episodic inflammatory ailment 1. Recent studies have shown that AD is a life-long disease that often begins in early childhood and that persists into adulthood. AD is at least in part associated with a dysfunctional skin barrier often due to loss of function (LOF) mutations of filaggrin (FLG) 2. Although the impact of FLG LOF on skin barrier function is less certain 3....

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