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Article

Loss-of-function mutations within the filaggrin gene and atopic dermatitis.

Current problems in dermatology - 1 Jan 2011

Kawasaki Hiroshi, Kubo Akiharu, Sasaki Takashi, Amagai Masayuki

Abstract excerpt

Atopic dermatitis (AD) is a chronic relapsing eczematous skin disorder that is frequently associated with elevated serum IgE levels and a personal or family history of AD, allergic rhinitis and/or asthma. Filaggrin is a major constituent of the stratum corneum (SC) and contributes to keratin filament aggregation. Its breakdown products form natural moisturizing factor, which plays a central role in hydration of...

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PMID: 21576945
DOI: 10.1159/000323291

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