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Article

Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function.

Neuron - 25 Sept 2008

Wang Rui, Walker Craig S, Brockie Penelope J, Francis Michael M, Mellem Jerry E, Madsen David M, Maricq Andres V

Abstract excerpt

Neurotransmission in the brain is critically dependent on excitatory synaptic signaling mediated by AMPA-class ionotropic glutamate receptors (AMPARs). AMPARs are known to be associated with Transmembrane AMPA receptor Regulatory Proteins (TARPs). In vertebrates, at least four TARPs appear to have redundant roles as obligate chaperones for AMPARs, thus greatly complicating analysis of TARP participation in...

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Source

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Identifiers

PMID: 18817737
DOI: 10.1016/j.neuron.2008.07.023
PMCID: PMC2754846

Genes

TARP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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