Article
Stargazin interacts functionally with the AMPA receptor glutamate-binding module.
Neuropharmacology - 1 Jan 2007
Tomita Susumu, Shenoy Archana, Fukata Yuko, Nicoll Roger A, Bredt David S
Abstract excerpt
Neuronal AMPA receptors comprise pore forming glutamate receptor (GluR) proteins and auxiliary transmembrane AMPA receptor regulatory (TARP) subunits. TARPs traffic AMPA receptors to synapses and regulate channel gating. Both intracellular and extracellular regions in TARPs regulate AMPA receptors; however, the details for these interactions remain unknown. Here, we employ site-directed mutagenesis to determine...
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