Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons.

Nature communications - 2 Mar 2016

Gu Xinglong, Mao Xia, Lussier Marc P, Hutchison Mary Anne, Zhou Liang, Hamra F Kent, Roche Katherine W, Lu Wei

Abstract excerpt

Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism for synaptic plasticity. In the brain, AMPARs assemble with a number of auxiliary subunits, including TARPs, CNIHs and CKAMP44, which are important for AMPAR forward trafficking to synapses. Here we report that the membrane protein GSG1L negatively regulates AMPAR-mediated synaptic transmission. Overexpression of GSG1L strongly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Synapses
Share to Claudins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Hippocampus

Share to Protein Subunits

Share to Real-Time Polymerase Chain Reaction

Share to Receptors, AMPA

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 26932439
DOI: 10.1038/ncomms10873
PMCID: PMC4778064

Genes

CNIH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons.PMID 26932439Read ↗

The role of transmembrane AMPA receptor regulatory proteins (TARPs) in neurotransmission and receptor trafficking (Review).Semantic proximity Read ↗

GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors.Semantic proximity Read ↗

Stargazin interacts functionally with the AMPA receptor glutamate-binding module.Semantic proximity Read ↗

Engineering defined membrane-embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin.Semantic proximity Read ↗

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability.Semantic proximity Read ↗

Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex.Semantic proximity Read ↗

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.Semantic proximity Read ↗

Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviorsSemantic proximity Read ↗

TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs.Semantic proximity Read ↗

AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive agingSemantic proximity Read ↗

Network Topology reveals disrupted AMPA receptor stabilization leads to an impaired LTD in epileptic synapsesSemantic proximity Read ↗

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.