Article
AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability.
Nature communications - 4 Jul 2017
Brechet Aline, Buchert Rebecca, Schwenk Jochen, Boudkkazi Sami, Zolles Gerd, Siquier-Pernet Karine, Schaber Irene, Bildl Wolfgang, Saadi Abdelkrim, Bole-Feysot Christine, Nitschke Patrick, Reis Andre, Sticht Heinrich, Al-Sanna'a Nouriya, Rolfs Arndt, Kulik Akos, Schulte Uwe, Colleaux Laurence, Abou Jamra Rami, Fakler Bernd
Abstract excerpt
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the endoplasmic reticulum (ER) and lack the core-subunits typical for AMPARs in the plasma membrane. Central components of...
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