Article
Cornichons control ER export of AMPA receptors to regulate synaptic excitability.
Neuron - 2 Oct 2013
Brockie Penelope J, Jensen Michael, Mellem Jerry E, Jensen Erica, Yamasaki Tokiwa, Wang Rui, Maxfield Dane, Thacker Colin, Hoerndli Frédéric, Dunn Patrick J, Tomita Susumu, Madsen David M, Maricq Andres V
Abstract excerpt
The strength of synaptic communication at central synapses depends on the number of ionotropic glutamate receptors, particularly the class gated by the agonist AMPA (AMPARs). Cornichon proteins, evolutionarily conserved endoplasmic reticulum cargo adaptors, modify the properties of vertebrate AMPARs when coexpressed in heterologous cells. However, the contribution of cornichons to behavior and in vivo nervous...
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