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Article

The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.

Molecular biology of the cell - 15 May 2015

Garafalo Steven D, Luth Eric S, Moss Benjamin J, Monteiro Michael I, Malkin Emily, Juo Peter

Abstract excerpt

Regulation of glutamate receptor (GluR) abundance at synapses by clathrin-mediated endocytosis can control synaptic strength and plasticity. We take advantage of viable, null mutations in subunits of the clathrin adaptor protein 2 (AP2) complex in Caenorhabditis elegans to characterize the in vivo role of AP2 in GluR trafficking. In contrast to our predictions for an endocytic adaptor, we found that levels of the...

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Identifiers

PMID: 25788288
DOI: 10.1091/mbc.E14-06-1048
PMCID: PMC4436833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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