Article
Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors.
Neuron - 18 Dec 2013
Hoerndli Frédéric J, Maxfield Dane A, Brockie Penelope J, Mellem Jerry E, Jensen Erica, Wang Rui, Madsen David M, Maricq Andres V
Abstract excerpt
A primary determinant of the strength of neurotransmission is the number of AMPA-type glutamate receptors (AMPARs) at synapses. However, we still lack a mechanistic understanding of how the number of synaptic AMPARs is regulated. Here, we show that UNC-116, the C. elegans homolog of vertebrate kinesin-1 heavy chain (KIF5), modifies synaptic strength by mediating the rapid delivery, removal, and redistribution of...
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