Article
Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jan 2010
Kim Kwang S, Yan Dan, Tomita Susumu
Abstract excerpt
Glutamate is a major excitatory neurotransmitter in the vertebrate brain. AMPA-type glutamate receptors mediate fast excitatory transmission. AMPA receptors assemble with transmembrane AMPA receptor regulatory protein (TARP) auxiliary subunits and function as native ion channels. However, the assembly and stoichiometry of AMPA receptor and TARP complexes remain unclear. Here, we developed a novel strategy to...
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