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Article

Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope.

Journal of virology - 1 Jan 2012

Ruhl Marianne, Chhatwal Patrick, Strathmann Heiko, Kuntzen Thomas, Bankwitz Dorothea, Skibbe Kathrin, Walker Andreas, Heinemann Falko M, Horn Peter A, Allen Todd M, Hoffmann Daniel, Pietschmann Thomas, Timm Jörg

Abstract excerpt

Antiviral CD8(+) T cells are a key component of the adaptive immune system against hepatitis C virus (HCV). For the development of immune therapies, it is essential to understand how CD8(+) T cells contribute to clearance of infection and why they fail so often. A mechanism for secondary failure is mutational escape of the virus. However, some substitutions in viral epitopes are associated with fitness costs and...

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Share to CD8-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis C

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Source

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Identifiers

PMID: 22072759
DOI: 10.1128/JVI.05603-11
PMCID: PMC3255842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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