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Article

CD8 epitope escape and reversion in acute HCV infection.

The Journal of experimental medicine - 20 Dec 2004

Timm Joerg, Lauer Georg M, Kavanagh Daniel G, Sheridan Isabelle, Kim Arthur Y, Lucas Michaela, Pillay Thillagavathie, Ouchi Kei, Reyor Laura L, Schulze zur Wiesch Julian, Gandhi Rajesh T, Chung Raymond T, Bhardwaj Nina, Klenerman Paul, Walker Bruce D, Allen Todd M

Abstract excerpt

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these responses, 70-80% of individuals develop persistent infection. Although viral escape from CD8 responses has been illustrated in the chimpanzee model of HCV infection, the effect of CD8 selection pressure on viral evolution and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

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Source

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Identifiers

PMID: 15611288
DOI: 10.1084/jem.20041006
PMCID: PMC2212005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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