Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

Neurogenetics - 1 Feb 2009

Kauwe John S K, Wang Jun, Mayo Kevin, Morris John C, Fagan Anne M, Holtzman David M, Goate Alison M

Abstract excerpt

The use of quantitative endophenotypes in genetic studies may provide greater power, allowing for the use of powerful statistical methods and a biological model for the effects of the disease-associated genetic variation. Cerebrospinal fluid (CSF) amyloid beta (Abeta) levels are promising endophenotypes for late-onset Alzheimer's disease (LOAD) and show correlation with LOAD status and Abeta deposition. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Databases, Genetic

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 18813964
DOI: 10.1007/s10048-008-0150-4
PMCID: PMC2726757

Genes

ACE
APOE
BDNF
DAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.PMID 18813964Read ↗

Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processingSemantic proximity Read ↗

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease.Semantic proximity Read ↗

Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.Semantic proximity Read ↗

Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.Semantic proximity Read ↗

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease.Semantic proximity Read ↗

Use of genetic variation as biomarkers for Alzheimer's disease.Semantic proximity Read ↗

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.Semantic proximity Read ↗

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.Semantic proximity Read ↗

Genetic architecture of plasma Alzheimer disease biomarkersSemantic proximity Read ↗

Shared genetic background between cerebrospinal fluid biomarkers and risk for Alzheimer’s disease: A two-sample Mendelian randomisation studySemantic proximity Read ↗

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.Semantic proximity Read ↗

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.