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Article

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease.

BMC medical genomics - 24 May 2017

Nho Kwangsik, Kim Sungeun, Horgusluoglu Emrin, Risacher Shannon L, Shen Li, Kim Dokyoon, Lee Seunggeun, Foroud Tatiana, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Petersen Ronald C, Jack Clifford R, Weiner Michael W, Green Robert C, Toga Arthur W, Saykin Andrew J

Abstract excerpt

BACKGROUND: The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer's disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common variants in the region remain significant after adjusting for APOE genotype. We report a rare variant association analysis of genes in the vicinity of APOE with cerebrospinal...

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Share to Alzheimer Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Chromosomes, Human, Pair 19

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 28589856
DOI: 10.1186/s12920-017-0267-0
PMCID: PMC5461522

Genes

APOE
CBLC
MAF
RELB
BCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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