Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.

doi:10.1093/hmg/ddm031

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Article

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.

Human molecular genetics - 15 Apr 2007

Grupe Andrew, Abraham Richard, Li Yonghong, Rowland Charles, Hollingworth Paul, Morgan Angharad, Jehu Luke, Segurado Ricardo, Stone David, Schadt Eric, Karnoub Maha, Nowotny Petra, Tacey Kristina, Catanese Joseph, Sninsky John, Brayne Carol, Rubinsztein David, Gill Michael, Lawlor Brian, Lovestone Simon, Holmans Peter, O'Donovan Michael, Morris John C, Thal Leon, Goate Alison, Owen Michael J, Williams Julie

Abstract excerpt

This study sets out to identify novel susceptibility genes for late-onset Alzheimer's disease (LOAD) in a powerful set of samples from the UK and USA (1808 LOAD cases and 2062 controls). Allele frequencies of 17 343 gene-based putative functional single nucleotide polymorphisms (SNPs) were tested for association with LOAD in a discovery case-control sample from the UK. A tiered strategy was used to follow-up...

Topics

Aged
Alzheimer Disease
Case-Control Studies
Chromosome Mapping
Female
Gene Silencing
Genetic Linkage
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Humans

Male

Middle Aged

Polymorphism, Single Nucleotide

United Kingdom

United States

Source

Open in PubMed

Identifiers

PMID: 17317784
DOI: 10.1093/hmg/ddm031

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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