Article
Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2008
Kauwe John S K, Cruchaga Carlos, Mayo Kevin, Fenoglio Chiara, Bertelsen Sarah, Nowotny Petra, Galimberti Daniela, Scarpini Elio, Morris John C, Fagan Anne M, Holtzman David M, Goate Alison M
Abstract excerpt
There is substantial evidence that cerebrospinal fluid (CSF) levels of both Abeta42 and tau/ptau are promising biomarkers for Alzheimer's disease (AD). We show that both Abeta and tau exhibit more than 10-fold interindividual variation in CSF levels suggesting that these biomarkers may also be effectively used as endophenotypes for genetic studies of AD. To test the role of common variation in the gene encoding...
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