Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease.

Human molecular genetics - 15 Oct 2012

Cruchaga Carlos, Kauwe John S K, Nowotny Petra, Bales Kelly, Pickering Eve H, Mayo Kevin, Bertelsen Sarah, Hinrichs Anthony, Fagan Anne M, Holtzman David M, Morris John C, Goate Alison M

Abstract excerpt

The apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer's disease (AD). We have access to cerebrospinal fluid (CSF) and plasma APOE protein levels from 641 individuals and genome-wide genotyped data from 570 of these samples. The aim of this study was to test whether CSF or plasma APOE levels could be a useful endophenotype for AD and to identify genetic variants associated with APOE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Case-Control Studies

Share to APOE gene

Share to Genotype

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 22821396
DOI: 10.1093/hmg/dds296
PMCID: PMC3459471

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease.PMID 22821396Read ↗

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease.Semantic proximity Read ↗

Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk.Semantic proximity Read ↗

Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels.Semantic proximity Read ↗

Cerebrospinal fluid proteomic signatures reveal APOE genotype-dependent lipid and immune profiles in cognitively unimpaired elderlySemantic proximity Read ↗

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.Semantic proximity Read ↗

Beyond the Genotype: A Multi-Omic Analysis of APOEe4’s Role in Alzheimer’s DiseaseSemantic proximity Read ↗

Novel Plasma Proteins Associated With Alzheimer’s Disease Risk in APOE ε4 Carriers and Non-carriersSemantic proximity Read ↗

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s Disease related proteinsSemantic proximity Read ↗

Plasma amyloid β levels are driven by genetic variants near <i>APOE, BACE1, APP, PSEN2:</i> A genome-wide association study in over 12,000 non-demented participantsSemantic proximity Read ↗

<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s diseaseSemantic proximity Read ↗

Neuropathology-based<i>APOE</i>genetic risk score better quantifies Alzheimer’s riskSemantic proximity Read ↗

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.