GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

doi:10.1016/j.neuron.2007.05.022

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Article

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

Neuron - 7 Jun 2007

Reiman Eric M, Webster Jennifer A, Myers Amanda J, Hardy John, Dunckley Travis, Zismann Victoria L, Joshipura Keta D, Pearson John V, Hu-Lince Diane, Huentelman Matthew J, Craig David W, Coon Keith D, Liang Winnie S, Herbert RiLee H, Beach Thomas, Rohrer Kristen C, Zhao Alice S, Leung Doris, Bryden Leslie, Marlowe Lauren, Kaleem Mona, Mastroeni Diego, Grover Andrew, Heward Christopher B, Ravid Rivka, Rogers Joseph, Hutton Michael L, Melquist Stacey, Petersen Ron C, Alexander Gene E, Caselli Richard J, Kukull Walter, Papassotiropoulos Andreas, Stephan Dietrich A

Abstract excerpt

The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotide polymorphisms (SNPs) to characterize and confirm other LOAD susceptibility genes. In epsilon4 carriers from neuropathologically verified discovery, neuropathologically verified replication, and clinically characterized...

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Identifiers

PMID: 17553421
DOI: 10.1016/j.neuron.2007.05.022
PMCID: PMC2587162

Genes

GAB2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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