Article
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
Neurology - 4 Jan 2011
Kim S, Swaminathan S, Shen L, Risacher S L, Nho K, Foroud T, Shaw L M, Trojanowski J Q, Potkin S G, Huentelman M J, Craig D W, DeChairo B M, Aisen P S, Petersen R C, Weiner M W, Saykin A J
Abstract excerpt
OBJECTIVES: CSF levels of Aβ1-42, t-tau, and p-tau181p are potential early diagnostic markers for probable Alzheimer disease (AD). The influence of genetic variation on these markers has been investigated for candidate genes but not on a genome-wide basis. We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42). METHODS: A total of 374...
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